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KMID : 0383820140760030120
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Tuberculosis and Respiratory Diseases
2014 Volume.76 No. 3 p.120 ~ p.126
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Apigenin and Wogonin Regulate Epidermal Growth Factor Receptor Signaling Pathway Involved in MUC5AC Mucin Gene Expression and Production from Cultured Airway Epithelial Cells
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Md. Asaduzzaman Sikder
Lee Hyun-Jae
Ryu Ji-Ho
Park Su-Hyun
Kim Ju-Ock
Hong Jang-Hee
Seok Jeong-Ho
Lee Choong-Jae
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Abstract
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Background: 1Department of Pharmacology, Chungnam National University School of Medicine, 2Pulmonology Section, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea
Materials and Methods: Confluent NCI-H292 cells were pretreated with wogonin or apigenin for 15 minutes or 24 hours and then stimulated with epidermal growth factor (EGF) for 24 hours or the indicated periods.
Results: We found that incubation of NCI-H292 cells with wogonin or apigenin inhibited the phosphorylation of EGFR. The downstream signals of EGFR such as phosphorylation of MEK1/2 and ERK1/2 were also inhibited by wogonin or apigenin.
Conclusion: The results suggest that wogonin and apigenin inhibits EGFR signaling pathway, which may explain how they inhibit MUC5AC mucin gene expression and production induced by EGF.
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KEYWORD
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Receptor, Epidermal Growth Factor, Mucins, Wogonin, Apigenin
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